This e-Seminar focus on structure searching on STNext. The STN structure editor is explained in detail, including how to draw a structure using specific atoms and/or rings, shortcuts, variables, and STN generic nodes. The session also explains how to draw variable points of attachment for a node, and atom locking (to prevent any substitution at that node) and ring locking (to prevent further ring fusion.) An example structure search is run in two substance databases (REGISTRY and DCR), and then the corresponding patent families are found in the patent family databases CAplus and Derwent World Patents Index, illustrating unique hits found in each database. This e-seminar is geared to all levels of searchers.